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1

Extraction of structured data from unstructured medical records using text data mining technologies: process automation

Moskalev, I V, Krotova, O S, Khvorova, L A, Bobkova, D G

Journal:

Journal of Physics Conference Series

Year:

2020

File:

PDF, 1.39 MB

2020

2

The chemical evolution of oligonucleotide therapies of clinical utility

Khvorova, Anastasia, Watts, Jonathan K

Journal:

Nature Biotechnology

Year:

2017

Language:

english

File:

PDF, 1015 KB

english, 2017

3

Corrigendum: Different delivery methods—different expression profiles

Fedorov, Yuriy, King, Alan, Anderson, Emily, Karpilow, Jon, Ilsley, Diane, Marshall, William, Khvorova, Anastasia

Journal:

Year:

2005

File:

PDF, 28 KB

2005

4

Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo

Sharma, Vivek Kumar, Osborn, Maire F., Hassler, Matthew, Echeverria, Dimas, Ly, Socheata, Ulashchik, Egor, Martynenko-Makaev, Yury, Shmanai, Vadim V, Zatsepin, Timofei S., Khvorova, Anastasia, Watts,

Journal:

Bioconjugate Chemistry

Year:

2018

Language:

english

File:

PDF, 953 KB

english, 2018

5

A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo

Coles, Andrew H., Osborn, Maire F., Alterman, Julia F., Turanov, Anton A., Godinho, Bruno M.D.C., Kennington, Lori, Chase, Kathryn, Aronin, Neil, Khvorova, Anastasia

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2015

Language:

english

File:

PDF, 532 KB

english, 2015

6

Data on enrichment of chitosan nanoparticles for intranasal delivery of oligonucleotides to the brain

Sava, Vasyl, Fihurka, Oksana, Khvorova, Anastasia, Sanchez-Ramos, Juan

Journal:

Year:

2020

File:

PDF, 516 KB

2020

7

Specificity and functionality of microRNA inhibitors

Barbara Robertson, Andrew B Dalby, Jon Karpilow, Anastasia Khvorova, Devin Leake, Annaleen Vermeulen

Journal:

Year:

2010

Language:

english

File:

PDF, 591 KB

english, 2010

8

RNAs that bind and change the permeability of phospholipid membranes

Khvorova, A., Kwak, Y.-G., Tamkun, M., Majerfeld, I., Yarus, M.

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 156 KB

english, 1999

9

Potent and systematic RNAi mediated silencing with single oligonucleotide compounds

Lapierre, J., Salomon, W., Cardia, J., Bulock, K., Lam, J. T., Stanney, W. J., Ford, G., Smith-Anzures, B., Woolf, T., Kamens, J., Khvorova, A., Samarsky, D.

Journal:

Year:

2011

Language:

english

File:

PDF, 582 KB

english, 2011

10

RNAs That Bind and Change the Permeability of Phospholipid Membranes

Anastasia Khvorova, Yong-Geun Kwak, Michael Tamkun, Irene Majerfeld and Michael Yarus

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 974 KB

english, 1999

11

SEDIMENTATION IN THE RIFT ZONE OF THE JUAN DE FUCA RIDGE

Bogdanov, Yu. A., Khvorova, I. V., Serova, V. V., Gorbunova, Z. N.

Journal:

International Geology Review

Year:

1989

Language:

english

File:

PDF, 854 KB

english, 1989

12

Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain

Sanchez-Ramos, Juan, Song, Shijie, Kong, Xiaoyuan, Foroutan, Parastou, Martinez, Gary, Dominguez-Viqueria, William, Mohapatra, Shyam, Mohapatra, Subra, Haraszti, Reka A., Khvorova, Anastasia, Aronin,

Journal:

Journal of Drug Delivery Science and Technology

Year:

2018

Language:

english

File:

PDF, 1.83 MB

english, 2018

13

Efficient gene silencing in brain tumors with hydrophobically modified siRNAs

Osborn, Maire F, Coles, Andrew H, Golebiowski, Diane, Echeverria, Dimas, Moazami, Michael P., Watts, Jonathan K., Sena-Esteves, Miguel, Khvorova, Anastasia

Journal:

Molecular Cancer Therapeutics

Year:

2018

Language:

english

File:

PDF, 3.52 MB

english, 2018

14

Improving Small Interfering RNA Delivery In Vivo Through Lipid Conjugation

Osborn, Maire F., Khvorova, Anastasia

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2018

Language:

english

File:

PDF, 708 KB

english, 2018

15

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

Biscans, Annabelle, Coles, Andrew, Haraszti, Reka, Echeverria, Dimas, Hassler, Matthew, Osborn, Maire, Khvorova, Anastasia

Journal:

Nucleic Acids Research

Year:

2018

Language:

english

File:

PDF, 12.99 MB

english, 2018

16

Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy

Ly, Socheata, Echeverria, Dimas, Sousa, Jacquelyn, Khvorova, Anastasia

Journal:

Molecular Therapy — Nucleic Acids

Year:

2020

File:

PDF, 5.71 MB

2020

17

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

Simpson, Kaylene J., Selfors, Laura M., Bui, James, Reynolds, Angela, Leake, Devin, Khvorova, Anastasia, Brugge, Joan S.

Journal:

Nature Cell Biology

Year:

2008

Language:

english

File:

PDF, 5.78 MB

english, 2008

18

Mimics of Yeast tRNA Asp and Their Recognition by Aspartyl-tRNA Synthetase †

Wolfson, Alexey D., Khvorova, Anastasia M., Sauter, Claude, Florentz, Catherine, Giegé, Richard

Journal:

Year:

1999

Language:

english

File:

PDF, 105 KB

english, 1999

19

Comparative Analysis of PKСα and PKCζ Activities in Rat and Lamprey Erythrocytes of Different Ages

Agalakova, N. I., Khvorova, I. A., Ivanova, T. I.

Journal:

Journal of Evolutionary Biochemistry and Physiology

Year:

2018

Language:

english

File:

PDF, 1.33 MB

english, 2018

20

Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity

Khvorova, Anastasia, Lescoute, Aurélie, Westhof, Eric, Jayasena, Sumedha D

Journal:

Natural Structural Biology

Year:

2003

Language:

english

File:

PDF, 626 KB

english, 2003

21

Double-stranded regions are essential design components of potent inhibitors of RISC function

Vermeulen, A., Robertson, B., Dalby, A. B., Marshall, W. S., Karpilow, J., Leake, D., Khvorova, A., Baskerville, S.

Journal:

Year:

2007

Language:

english

File:

PDF, 565 KB

english, 2007

22

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

Haraszti, Reka A., Didiot, Marie-Cecile, Sapp, Ellen, Leszyk, John, Shaffer, Scott A., Rockwell, Hannah E., Gao, Fei, Narain, Niven R., DiFiglia, Marian, Kiebish, Michael A., Aronin, Neil, Khvorova, A

Journal:

Journal of Extracellular Vesicles

Year:

2016

Language:

english

File:

PDF, 3.36 MB

english, 2016

23

The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo

Biscans, Annabelle, Coles, Andrew, Echeverria, Dimas, Khvorova, Anastasia

Journal:

Journal of Controlled Release

Year:

2019

Language:

english

File:

PDF, 1.98 MB

english, 2019

24

Functional siRNAs and miRNAs Exhibit Strand Bias

Anastasia Khvorova, Angela Reynolds, Sumedha D. Jayasena

Journal:

Year:

2003

Language:

english

File:

PDF, 443 KB

english, 2003

25

Fast Cleavage Kinetics of a Natural Hammerhead Ribozyme

Canny, Marella D., Jucker, Fiona M., Kellogg, Elizabeth, Khvorova, Anastasia, Jayasena, Sumedha D., Pardi, Arthur

Journal:

Journal of the American Chemical Society

Year:

2004

Language:

english

File:

PDF, 43 KB

english, 2004

26

ChemInform Abstract: Triazenes: Reactivity and Mechanism of the Antineoplastic Effect. Part 5. Reaction of Aromatic Diazonium Compounds (I) with L-Prolinemethylamide (II).

NIFONTOV, V. I., BEL'SKAYA, N. P., CHERNOV, V. A., GALYAMOVA, I. V., KHVOROVA, N. M., SMAL'KO, M. A., KRUPNOVA, L. V., DARIENKO, E. P.

Journal:

Year:

1989

File:

PDF, 102 KB

1989

27

Synthesis and biological properties of triazole-linked locked nucleic acid

Sharma, Vivek, Singh, Sunil, Krishnamurthy, Pranathi Meda, Alterman, Julia, Haraszti, Reka, Khvorova, Anastasia, Prasad, Ashok K, Watts, Jonathan

Journal:

Chemical Communications

Year:

2017

Language:

english

File:

PDF, 943 KB

english, 2017

28

Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference

Ferguson, Chantal M., Echeverria, Dimas, Hassler, Matthew, Ly, Socheata, Khvorova, Anastasia

Journal:

Molecular Therapy — Nucleic Acids

Year:

2020

File:

PDF, 1.29 MB

2020

29

Analysis of Clathrin-mediated Endocytosis of Epidermal Growth Factor Receptor by RNA Interference

Huang, F., Khvorova, A., Marshall, W., Sorkin, A.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 652 KB

english, 2004

30

Corrigendum: Taking charge of siRNA delivery

Khvorova, Anastasia, Osborn, Maire F, Hassler, Matthew R

Journal:

Nature Biotechnology

Year:

2015

Language:

english

File:

PDF, 96 KB

english, 2015

31

5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo

Haraszti, Reka A., Roux, Loic, Coles, Andrew H., Turanov, Anton A., Alterman, Julia F., Echeverria, Dimas, Godinho, Bruno M.D.C., Aronin, Neil, Khvorova, Anastasia

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 5.41 MB

english, 2017

32

Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles

Biscans, Annabelle, Haraszti, Reka A., Echeverria, Dimas, Miller, Rachael, Didiot, Marie-Cecile, Nikan, Mehran, Roux, Loic, Aronin, Neil, Khvorova, Anastasia

Journal:

Molecular Therapy

Year:

2018

Language:

english

File:

PDF, 1.64 MB

english, 2018

33

Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing

Mir, Aamir, Alterman, Julia F., Hassler, Matthew R., Debacker, Alexandre J., Hudgens, Edward, Echeverria, Dimas, Brodsky, Michael H., Khvorova, Anastasia, Watts, Jonathan K., Sontheimer, Erik J.

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 1.06 MB

english, 2018

34

Nucleic Acid Therapeutics for Neurological Diseases

Watts, Jonathan K., Brown, Robert H., Khvorova, Anastasia

Journal:

Neurotherapeutics

Year:

2019

Language:

english

File:

PDF, 171 KB

english, 2019

35

Enriched chitosan nanoparticles loaded with siRNA are effective in lowering Huntington's disease gene expression following intranasal administration

Sava, Vasyl, Fihurka, Oksana, Khvorova, Anastasia, Sanchez-Ramos, Juan

Journal:

Nanomedicine: Nanotechnology, Biology and Medicine

Year:

2019

Language:

english

File:

PDF, 1.03 MB

english, 2019

36

A protocol for designing siRNAs with high functionality and specificity

Birmingham, Amanda, Anderson, Emily, Sullivan, Kevin, Reynolds, Angela, Boese, Queta, Leake, Devin, Karpilow, Jon, Khvorova, Anastasia

Journal:

Nature Protocols

Year:

2007

Language:

english

File:

PDF, 511 KB

english, 2007

37

Synthesis of derivatives of the androstane series. XXI. Synthesis and properties of some N-acylated androstano[3,2-c]pyrazoles

L. N. Volovel'skii, N. M. Khvorova, I. I. Kuz'menko, S. N. Ushenko

Journal:

Chemistry of Natural Compounds

Year:

1981

Language:

english

File:

PDF, 410 KB

english, 1981

38

Reaction of aromatic diazo derivatives with glycine and glycine methylamide

V. I. Nifontov, N. P. Bel'skaya, O. A. Bagaeva, L. V. Krupnova, N. M. Khvorova, M. A. Bobarykina

Journal:

Pharmaceutical Chemistry Journal

Year:

1990

Language:

english

File:

PDF, 280 KB

english, 1990

39

Defining the optimal parameters for hairpin-based knockdown constructs

Li, L., Lin, X., Khvorova, A., Fesik, S. W., Shen, Y.

Journal:

Year:

2007

Language:

english

File:

PDF, 692 KB

english, 2007

40

Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System

Haraszti, Reka, Coles, Andrew, Aronin, Neil, Khvorova, Anastasia, Didiot, Marie-Cécile

Journal:

Year:

2017

Language:

english

File:

PDF, 369 KB

english, 2017

41

035 AIM2 regulates anti-tumor immunity from dendritic cell vaccination within the melanoma microenvironment

Fukuda, K., Riding, R., Khvorova, A., Fitzgerald, K., Harris, J.E.

Journal:

The Journal of Investigative Dermatology

Year:

2019

Language:

english

File:

PDF, 193 KB

english, 2019

42

RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells

Wilson, J. A., Jayasena, S., Khvorova, A., Sabatinos, S., Rodrigue-Gervais, I. G., Arya, S., Sarangi, F., Harris-Brandts, M., Beaulieu, S., Richardson, C. D.

Journal:

Proceedings of the National Academy of Sciences

Year:

2003

Language:

english

File:

PDF, 265 KB

english, 2003

43

Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain

Nikan, Mehran, Osborn, Maire F, Coles, Andrew H, Godinho, Bruno MDC, Hall, Lauren M, Haraszti, Reka A, Hassler, Matthew R, Echeverria, Dimas, Aronin, Neil, Khvorova, Anastasia

Journal:

Molecular Therapy — Nucleic Acids

Year:

2016

Language:

english

File:

PDF, 3.12 MB

english, 2016

44

Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay

Godinho, Bruno M.D.C., Gilbert, James W., Haraszti, Reka A., Coles, Andrew H., Biscans, Annabelle, Roux, Loic, Nikan, Mehran, Echeverria, Dimas, Hassler, Matthew, Khvorova, Anastasia

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2017

Language:

english

File:

PDF, 644 KB

english, 2017

45

The Different Role of High-Affinity and Low-Affinity Metal Ions in Cleavage by a Tertiary Stabilized Cis Hammerhead Ribozyme from Tobacco Ringspot Virus

Kisseleva, Natalia, Khvorova, Anastasia, Westhof, Eric, Schiemann, Olav, Wolfson, Alexey D.

Journal:

Oligonucleotides

Year:

2008

Language:

english

File:

PDF, 458 KB

english, 2008

46

ChemInform Abstract: Synthesis and Cytostatic Activity of N-(Chloroethylaminoethyl)-4-chloro-L-proline Ethyl Ester.

KHVOROVA, N. M., KLYUEV, N. A., NIFONTOV, V. I., PUSHKAREVA, Z. V., BOBARYKINA, K. YU., SMAL'KO, M. A., ANOSHINA, G. M.

Journal:

Year:

1987

File:

PDF, 120 KB

1987

47

Synthesis and cytostatic activity of N-(chloroethylaminoethyl)-4-chloro-1-proline ethyl ester

N. M. Khvorova, N. A. Klyuev, V. I. Nifontov, Z. V. Pushkareva, K. Yu. Bobarykina, M. A. Smal'ko, G. M. Anoshina

Journal:

Pharmaceutical Chemistry Journal

Year:

1986

Language:

english

File:

PDF, 290 KB

english, 1986

48

Interaction of F-actin with phosphate analogues studied by differential scanning calorimetry

Olga P. Nikolaeva, Irina V. Dedova, Irina S. Khvorova, Dmitrii I. Levitsky

Journal:

Year:

1994

Language:

english

File:

PDF, 419 KB

english, 1994

49

New competition in RNA regulation

Khvorova, Anastasia, Wolfson, Alexey

Journal:

Nature Biotechnology

Year:

2012

Language:

english

File:

PDF, 6.02 MB

english, 2012

50

Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable, O -phosphocholine- N -docosahexaenoyl-L-serine siRNA Conjugate in Mouse Brain

Nikan, Mehran, Osborn, Maire F., Coles, Andrew H, Biscans, Annabelle, Godinho, Bruno, Haraszti, Reka, Sapp, Ellen, Echeverria, Dimas, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

Journal:

Bioconjugate Chemistry

Year:

2017

Language:

english

File:

PDF, 1.24 MB

english, 2017

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